Hyperimmune Sera in the Treatment and Prevention of Diarrhea in Neonatal Calves

Abstract

This study assesses the efficacy of hyperimmune sera for the specific prevention of infectious diarrhea in neonatal calves, a major concern in veterinary medicine due to its impact on animal health and farm productivity. The study involved biochemical and hematological blood analyses performed on calves, which were divided into control and experimental groups based on the presence of infectious diseases. The biochemical analysis focused on key enzyme levels, protein fractions, creatinine, and other biomarkers that reflect the functional state of vital organs, such as the liver and kidneys. Hematological analysis was used to identify changes in blood composition indicative of inflammation and immune response. The results showed that the administration of hyperimmune sera significantly reduced the incidence of diarrhea in the experimental group by 60–80%, as compared to the control group. Additionally, mortality rates were also reduced by 30–50% in calves treated with hyperimmune sera. The biochemical findings revealed a decrease in transaminase activity, which suggests reduced liver stress, alongside the normalization of protein fraction levels. Furthermore, erythrocyte-related blood parameters were significantly improved, indicating enhanced overall health and immune function. These findings underscore the potential of hyperimmune sera as a highly effective preventive measure against infectious diarrhea in calves. The treatment not only mitigated clinical symptoms but also improved the general health status of the animals. This approach represents a promising and valuable tool for controlling infectious diseases and enhancing the welfare of neonatal calves in both clinical and farm settings.